When Does Mls Schedule Come Out 2025. The 2025 mls season kicks off with the mls is back weekend on saturday, february 22 and sunday, february 23. Every match of the 2025 regular season, mls cup playoffs,.

All 30 mls clubs will be in action as mls kicks off its 30th season campaign during the mls is back. San diego fc will begin their inaugural season at the la galaxy during mls is back weekend (feb.